Invention Grant
- Patent Title: Method for generating T cells progenitors
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Application No.: US17173632Application Date: 2021-02-11
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Publication No.: US11638723B2Publication Date: 2023-05-02
- Inventor: Isabelle André , Marina Cavazzana , Kuiying Ma , John Tchen , Tayebeh-Shabi Soheili , Ranjita Devi Moirangthem
- Applicant: Assistance Publique—Hopitaux de Paris , Fondation Imagine—Institut des Maladies Génétiques , Université Paris Cité , Institut National de la Santé et de la Recherche Médicale (INSERM)
- Applicant Address: FR Paris; FR Paris; FR Paris; FR Paris
- Assignee: Assistance Publique—Hopitaux de Paris,Fondation Imagine—Institut des Maladies Génétiques,Université Paris Cité,Institut National de la Santé et de la Recherche Médicale (INSERM)
- Current Assignee: Assistance Publique—Hopitaux de Paris,Fondation Imagine—Institut des Maladies Génétiques,Université Paris Cité,Institut National de la Santé et de la Recherche Médicale (INSERM)
- Current Assignee Address: FR Paris; FR Paris; FR Paris; FR Paris
- Agency: Panitch Schwarze Belisario & Nadel LLP
- Agent Erin M. Dunston
- Priority: EP17305161 20170213
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N15/63 ; C12N5/02 ; A61K35/17 ; C12N5/0783 ; A61K31/70
Abstract:
The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydrocarbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
Public/Granted literature
- US20210169934A1 METHOD FOR GENERATING T CELLS PROGENITORS Public/Granted day:2021-06-10
Information query
