Invention Grant
- Patent Title: Asymmetric bisaminoquinolines and bisaminoquinolines with varied linkers as autophagy inhibitors for cancer and other therapy
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Application No.: US17229012Application Date: 2021-04-13
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Publication No.: US11639335B2Publication Date: 2023-05-02
- Inventor: Ravi K. Amaravadi , Jeffrey D. Winkler
- Applicant: The Trustees of the University of Pennsylvania
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: BakerHostetler
- Main IPC: C07D215/46
- IPC: C07D215/46 ; A61K31/4706 ; A61K31/4709 ; C07D401/12 ; A61K31/436 ; A61K31/4375 ; A61K31/4545 ; A61K31/4745 ; A61K31/4995 ; A61K31/506 ; A61K31/517 ; A61K31/519 ; A61K31/704 ; A61K31/7056
Abstract:
The invention provides novel asymmetric and symmetric bisaminoquinolmes and related compounds, methods of treatment and syntheses. The novel compounds exhibit effective anticancer activity and are useful in the treatment of a variety of autophagy-related disorders.
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