This invention provides a method for creating a large-scale of amphiphilic particles. The method includes: adding nanoparticles into a polycarbonate-based solution, adding a surfactant into the solution while performing ultra-sonication to generate polymer precipitation, creating at least one microsphere with the nanoparticles embedded onto it, subjecting the exposed hemisphere of the embedded nanoparticles to a further amphiphilic particles related modification, and dissolving the at least one microsphere in a polycarbonate-based solution in order to free said embedded nanoparticles from the at least one microsphere.