Invention Grant
- Patent Title: Method of residue proximity information and protein model discrimination using saturation-suppressor mutagenesis
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Application No.: US15779800Application Date: 2016-11-18
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Publication No.: US11639500B2Publication Date: 2023-05-02
- Inventor: Varadarajan Raghavan , Anusmita Sahoo , Shruti Khare , Pankaj Jain , Shahbaz Ahmed , Kritika Gupta
- Applicant: Indian Institute of Science
- Applicant Address: IN Bangalore
- Assignee: Indian Institute of Science
- Current Assignee: Indian Institute of Science
- Current Assignee Address: IN Bangalore
- Agency: Thompson Coburn LLP
- Agent William A. Holtz
- Priority: IN6466/CHE/2015 20151201
- International Application: PCT/IN2016/050413 WO 20161118
- International Announcement: WO2017/094024 WO 20170608
- Main IPC: C12N15/10
- IPC: C12N15/10 ; G16B15/00 ; G16B20/00
Abstract:
The present disclosure relates to a method of protein structure and amino acid residue interaction prediction based on saturation suppressor mutagenesis screening of a protein of interest. The method of the instant disclosure can be adapted for multi-protein complexes, and is useful where crystal structure of a protein of interest is not available.
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