Invention Grant
- Patent Title: Methods and compositions for dual glycan binding AAV2.5 vector
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Application No.: US17581639Application Date: 2022-01-21
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Publication No.: US11639509B2Publication Date: 2023-05-02
- Inventor: Richard Jude Samulski
- Applicant: The University of North Carolina at Chapel Hill
- Applicant Address: US NC Chapel Hill
- Assignee: The University of North Carolina at Chapel Hill
- Current Assignee: The University of North Carolina at Chapel Hill
- Current Assignee Address: US NC Chapel Hill
- Agency: Myers Bigel, P.A.
- Main IPC: C12N15/86
- IPC: C12N15/86 ; A61P31/18 ; A61P31/20 ; A61P1/16 ; C07K14/005 ; C12N7/00
Abstract:
Disclosed herein are methods and compositions comprising an adeno-associated virus 2.5 (AAV2.5) capsid protein, comprising one or more amino acids substitutions, (e.g., which does not contain a substitution at the position corresponding to amino acid 267 of AAV2.5, or does not contain a serine at the position corresponding to amino acid 267 of AAV2.5) wherein the substitutions introduce a new glycan binding site into the AAV capsid protein.
Public/Granted literature
- US20220136010A1 METHODS AND COMPOSITIONS FOR DUAL GLYCAN BINDING AAV2.5 VECTOR Public/Granted day:2022-05-05
Information query
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