A portable refrigeration system for use in transport of medicines or other valuable, temperature sensitive materials is disclosed. The system can use GPS positioning technology to provide absolute global location along with internet connection through a cellular modem on board which allows for communication to the cloud of temperature and transit data during device use. The refrigerator 10 can be powered by a rechargeable battery back that may be recharged through connection to AC mains supply or connection to the photovoltaic panel 26 included with the device 10. The insulated container can be held at a constant temperature through the use of vacuum insulated panel construction. The device 10 can be cooled through the use of thermoelectric cooling modules 68 coupled to the insulated chamber 74 and paired with a heat exchanger 56 with heat pipes 60 and a system fan 54. The device 10 can be operated either through the included graphical user interface display 20 via touch or buttons or it may be accessed and controlled by a remote computer 80 through the cloud via a cellular connection 78.