The present disclosure provides a pixel rendering method, a pixel rendering device, a computer readable storage medium, and a display panel. The method includes: receiving an initial data signal for driving a target sub-pixel to display; determining a data range where the initial data signal is located, where different data ranges correspond to different display modes; determining a weight of color, shared by the target sub-pixel, of a sub-pixel around the target sub-pixel and having the same color as the target sub-pixel according to the data range, where the weight of color is varied in the different display modes; calculating a target data signal of the target sub-pixel according to the weight of color; and outputting the target data signal to the target sub-pixel.