Systems and methods for asynchronous communication are disclosed. For example, a method for asynchronous communication includes encoding, by a transmitter circuit and according to a first clock signal, a bit sequence by converting a one-bit in the bit sequence into a first sequence and a zero-bit in the bit sequence into a second sequence. A length of the first sequence and a length of the second sequence differ by at least three bits. The method also includes communicating, by the transmitter circuit, the first sequence and the second sequence to a receiver circuit that decodes the first sequence and the second sequence according to a second clock signal that is independent of the first clock signal.