Invention Grant
- Patent Title: N-pyridinyl acetamide derivatives as inhibitors of the WNT signaling pathway
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Application No.: US17009322Application Date: 2020-09-01
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Publication No.: US11643408B2Publication Date: 2023-05-09
- Inventor: Inder Bhamra , Matilda Bingham , Richard Testar , Louise Sargent , Craig Donoghue
- Applicant: Redx Pharma PLC
- Applicant Address: GB Macclesfield
- Assignee: Redx Pharma PLC
- Current Assignee: Redx Pharma PLC
- Current Assignee Address: GB Macclesfield
- Agency: Foley Hoag LLP
- Priority: GB 17829 2014.10.08 GB 11387 2015.06.29
- The original application number of the division: US16037879 2018.07.17
- Main IPC: C07D417/14
- IPC: C07D417/14 ; A61K31/444 ; A61K31/506 ; A61K31/501 ; A61P35/00 ; C07D401/14 ; A61K31/496 ; A61K31/497 ; A61K31/5377 ; C07D405/14 ; C07D413/14 ; C07D409/14 ; A61K45/06

Abstract:
This invention relates to compounds. More specifically, the invention relates to compounds useful as inhibitors of the Wnt signalling pathway. Specifically, inhibitors of Porcupine (Porcn) are contemplated by the invention. In addition the invention contemplates processes to prepare the compounds and uses of the compounds. The compounds of the invention may therefore be used in treating conditions mediated by the Wnt signalling pathway, for example treating cancer, sarcoma, melanoma, skin cancer, haematological tumors, lymphoma, carcinoma, and leukemia; or enhancing the effectiveness of an anti-cancer treatment.
Public/Granted literature
- US20210046076A1 N-PYRIDINYL ACETAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALING PATHWAY Public/Granted day:2021-02-18
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