Invention Grant
- Patent Title: Progranulin variants
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Application No.: US17697771Application Date: 2022-03-17
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Publication No.: US11643446B2Publication Date: 2023-05-09
- Inventor: Gerald Maxwell Cherf , Gunasekaran Kannan , Katrina W. Lexa , Ray L. Y. Low , Rachel Prorok , Ankita Srivastava
- Applicant: Denali Therapeutics Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Denali Therapeutics Inc.
- Current Assignee: Denali Therapeutics Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: C07K14/47
- IPC: C07K14/47 ; A61P25/28 ; C07K14/475 ; A61K38/00
Abstract:
Provided herein are progranulin variants and fusion proteins that comprise a progranulin variant and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.
Public/Granted literature
- US20220213155A1 PROGRANULIN VARIANTS Public/Granted day:2022-07-07
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