Invention Grant
- Patent Title: T cell-antigen coupler with Y182T mutation and methods and uses thereof
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Application No.: US16753577Application Date: 2018-10-12
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Publication No.: US11643472B2Publication Date: 2023-05-09
- Inventor: Christopher W. Helsen , Jonathan Bramson , Anna Dvorkin-Gheva , Galina F. Denisova , Ksenia Bezverbnaya , Kenneth Anthony Mwawasi
- Applicant: McMaster University
- Applicant Address: CA Hamilton
- Assignee: McMaster University
- Current Assignee: McMaster University
- Current Assignee Address: CA Hamilton
- Agency: Goodwin Procter LLP
- International Application: PCT/CA2018/051290 2018.10.12
- International Announcement: WO2019/071358A 2019.04.18
- Date entered country: 2020-04-03
- Main IPC: C07K16/30
- IPC: C07K16/30 ; A61P35/00 ; A61K9/00 ; A61K38/00 ; C07K14/725 ; C07K14/73 ; C07K16/28 ; A61K39/385 ; C07K14/525 ; C07K14/705
Abstract:
A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
Information query
