A chromatography-mass spectrometry method and apparatus of the present invention includes adding, to a sample, an internal standard material having a retention time similar to that of a target analyte and having a mass-to-charge ratio different from that of the target analyte; measuring the sample with a chromatograph-mass spectrometer and obtaining a chromatogram 101 of the target analyte and a chromatogram 102 of the internal standard material; detecting a peak 113 from the chromatogram of the internal standard material and obtaining a peak start time and a peak end time of the peak; and applying the obtained peak start time and peak end time to a peak start time and a peak end time of the chromatogram of the target analyte.