A method is provided for automatically or semi-automatically analyzing process hazards and validating protection mechanisms for an industrial process. The method can involve establishing communication between a simulation tool and a process hazard analysis tool. The simulation tool simulates operation of the process according to a process model. The method can further involve creating, using the process hazard analysis tool, conditions for hazards in the process based on information learned about the industrial process from the simulation tool; for each of the hazards, simulating the hazards using the simulation tool and attempting to prevent the hazards using the process hazard analysis tool by introducing protective mechanism(s) to the process; and evaluating effectiveness of the introduced protective mechanisms for each of the hazards and creating safety requirements for the process based on the evaluated effectiveness. The safety requirements are used to generate a safety application program, such as for a PLC.