A system for biologically determined artificial intelligence selection guidance includes a computing device designed and configured to receive at least a biological extraction and an item descriptor from a user, generate, using a classification algorithm and a plurality of past extractions, a user classifier matching user data to user sets, identify, using the classifier and the element user data, a user set identifier matching the user, produce a selection guidance using the user set identifier and the item category identifier, and provide the selection guidance to the user.