A method and a system for learning and applying neuro-symbolic multi-hop rules are provided. The method includes inputting training texts into a neural network as well as pre-defined entities. The training texts and the entities relate to a specific domain. The method also includes generating an entity graph made up of nodes and edges. The nodes represent the pre-defined entities, and the edges represent passages in the training texts with co-occurrence of the entities connected together by the edges. The method further includes determining a relation based on the passages for each of the pre-defined entities connected together by the edges, calculating a probability relating to the relation, generating a potential reasoning path between a head entity and a target entity. The method also includes learning a neuro-symbolic rule by converting the edges along the potential reasoning path into symbolic rules and combining those rules into the neuro-symbolic rule.