Systems and methods for establishing a multipath connection include a first processor of a first cluster forwarding a first request from a client to establish a first connection with a server to a second processor of a second cluster. A third processor of the first cluster receives a second request to establish a multipath connection between the client and the server. The third processor forwards the second request to the second processor responsive to determining that the second request is to establish a multipath connection. The second processor establishes the multipath connection that includes the first connection and a second connection used as paths of the multipath connection.