Invention Grant
- Patent Title: Method and compounds for inhibiting the MCM complex and their application in cancer treatment
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Application No.: US14399960Application Date: 2013-05-09
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Publication No.: US11648258B2Publication Date: 2023-05-16
- Inventor: Chun Liang , Zhihong Jiang , Ziyi Wang , Zhiling Yu , Jingrong Wang , Liping Bai
- Applicant: The Hong Kong University Of Science And Technology , Hong Kong Baptist University , Macau University Of Science And Technology
- Applicant Address: CN Kowloon
- Assignee: The Hong Kong University Of Science And Technology,Hong Kong Baptist University,Macau University Of Science And Technology
- Current Assignee: The Hong Kong University Of Science And Technology,Hong Kong Baptist University,Macau University Of Science And Technology
- Current Assignee Address: CN Kowloon; CN Kowloon; CN Macao
- Agency: Bayramoglu Law Offices LLC
- International Application: PCT/US2013/040287 2013.05.09
- International Announcement: WO2013/169989A 2013.11.14
- Date entered country: 2014-11-09
- Main IPC: A61K31/7048
- IPC: A61K31/7048 ; A61K31/585 ; G01N33/50 ; G01N33/574
Abstract:
A method for treating cancer by using an agent which is capable of inhibiting the functionality of the MCM complex, a heterohexameric ring formed from six subunits, in the process of DNA replication and a method of screening for such agents by detecting the locations and functions of the MCM subunits, such as hMcm2 and hMcm6, in cells treated with candidate compounds.
Public/Granted literature
- US20150099712A1 METHOD AND COMPOUNDS FOR INHIBITING THE MCM COMPLEX AND THEIR APPLICATION IN CANCER TREATMENT Public/Granted day:2015-04-09
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