Sound-generating toys are disclosed herein. In some embodiments, a sound-generating toy includes a squeezable body defining an internal chamber. A sound-generating module is positioned within the chamber. The module can include a housing containing (i) an airflow sensor configured to detect a pressure change in the chamber, (ii) a speaker configured to generate an audio output, and (iii) programmable circuitry operably coupled to the airflow sensor and the speaker. In operation, the airflow sensor can detect a pressure change in the chamber caused by a user squeezing the body of the toy, and can output a signal to the programmable circuitry indicating the pressure change. After receiving the signal indicating the pressure change, the programmable circuitry can drive the speaker to generate the audio output.