An air filtration system includes a frame directing an airflow through the air filtration system and a media filter disposed in the frame including one or more filtration elements. The system further includes one or more alignment features and one or more sealing elements interactive with the one or more alignment features to prevent incorrect installation of the media filter into the frame. A method of installing a media filter in an air filtration system includes aligning an alignment feature of the media filter with an opening in a frame of the air filtration system and inserting the media filter into the frame. The alignment feature ensures that the media filter is inserted in the frame in a correct orientation.