A protection system and method for cargos in a compartment and a robotic equipment thereof, applied in the field of robotics, are disclosed. The system includes an inflatable mechanism and an airbag. The airbag is used for filling the space between the cargos and/or between the cargos and an inner wall of the compartment. The airbag includes an inlet. The inflatable mechanism is defined on a robot for inflating or deflating the airbag via the inlet. The protection system and method for cargos in a compartment and a robotic equipment thereof can improve the stability of the stacked cargos during the process of the loading and unloading of the cargos, and the stability of the cargos during transportation.