Systems and methods for avoiding or mitigating motion sickness in a vehicle are disclosed herein. The systems and methods may include (a) determining a profile of the individual inclination towards motion sickness; (b) predicting an individual effectiveness of countermeasures based on typing using the data from step (a); (c) evaluating the actual effectiveness of the predicted countermeasures after their implementation when travelling in the vehicle; wherein step (a) is repeated regularly and all data and results from step (c) are fed into a self-learning system in order to obtain an improved statement on the individual actual effectiveness of countermeasures taken and to make the selection of effective countermeasures based on them.