Invention Grant
- Patent Title: Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators
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Application No.: US17239364Application Date: 2021-04-23
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Publication No.: US11649242B2Publication Date: 2023-05-16
- Inventor: Anna Ericsson , Neal Green , Gary Gustafson , Bingsong Han , David R. Lancia, Jr. , Lorna Mitchell , David Richard , Tatiana Shelekhin , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng
- Applicant: FORMA Therapeutics, Inc.
- Applicant Address: US MA Watertown
- Assignee: FORMA THERAPEUTICS, INC.
- Current Assignee: FORMA THERAPEUTICS, INC.
- Current Assignee Address: US MA Watertown
- Agency: Barnes & Thornburg LLP
- Agent Joshua E. Ney; Steven M. Sturlis
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D519/00 ; A61P7/00 ; A61K9/00 ; A61K31/407
Abstract:
The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.
Public/Granted literature
- US20210246143A1 PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS Public/Granted day:2021-08-12
Information query
