Invention Grant
- Patent Title: Biomarker for detecting a possible incompatability with respect to metal implants
-
Application No.: US16971692Application Date: 2019-02-04
-
Publication No.: US11649501B2Publication Date: 2023-05-16
- Inventor: Burkhard Summer , Peter Thomas , Sylvia Usbeck , Diana Lill
- Applicant: KLINIKUM DER UNIVERSITAET MUENCHEN
- Applicant Address: DE Munich
- Assignee: KLINIKUM DER UNIVERSITAET MUENCHEN
- Current Assignee: KLINIKUM DER UNIVERSITAET MUENCHEN
- Current Assignee Address: DE Munich
- Agent Norman B. Thot
- Priority: DE 2018104133.0 2018.02.23
- International Application: PCT/DE2019/200006 2019.02.04
- International Announcement: WO2019/161853A 2019.08.29
- Date entered country: 2020-11-02
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12P19/34 ; C12Q1/6883

Abstract:
A method to predict an increased risk of a greater susceptibility to a metal implant sensitivity in a test person. The method includes providing an isolated sample with a genetic material of the test person, and examining a single nucleotide polymorphism rs1143627
SEQ ID NO: 1
AGCCTCCTACTTCTGCTTTTGAAAGC[C/T]ATAAAA
ACAGCGAGGGAGAACTGG,
in a gene coding for interleukin 1 beta and ascertaining whether a C is present at a position of the single nucleotide polymorphism, and/or examining a VNTR polymorphism rs2234663 with the repeat
SEQ ID NO: 2
ATCCTGGGGAAAGTGAGGGAAATATGGACATCACATGGAACAACAT
CCAGGAGACTCAGGCCTCTAGGAGTAACTGGGTAGTGTGC,
in a gene coding for a IL1 receptor antagonist, IL1-RN and ascertaining whether the repeat is present five times.
SEQ ID NO: 1
AGCCTCCTACTTCTGCTTTTGAAAGC[C/T]ATAAAA
ACAGCGAGGGAGAACTGG,
in a gene coding for interleukin 1 beta and ascertaining whether a C is present at a position of the single nucleotide polymorphism, and/or examining a VNTR polymorphism rs2234663 with the repeat
SEQ ID NO: 2
ATCCTGGGGAAAGTGAGGGAAATATGGACATCACATGGAACAACAT
CCAGGAGACTCAGGCCTCTAGGAGTAACTGGGTAGTGTGC,
in a gene coding for a IL1 receptor antagonist, IL1-RN and ascertaining whether the repeat is present five times.
Public/Granted literature
- US20210054460A1 BIOMARKER FOR DETECTING A POSSIBLE INCOMPATABILITY WITH RESPECT TO METAL IMPLANTS Public/Granted day:2021-02-25
Information query