Invention Grant
- Patent Title: Anastasis biosensor caspase tracker
-
Application No.: US16763849Application Date: 2018-11-16
-
Publication No.: US11649509B2Publication Date: 2023-05-16
- Inventor: Ho Lam Hogan Tang , Ho Man Holly Tang
- Applicant: THE JOHNS HOPKINS UNIVERSITY
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: Johns Hopkins Technology Ventures
- International Application: PCT/US2018/061428 2018.11.16
- International Announcement: WO2019/099769A 2019.05.23
- Date entered country: 2020-05-13
- Main IPC: C07K14/00
- IPC: C07K14/00 ; C12Q1/34 ; C12Q1/6897
Abstract:
The present invention relates to the field of anastasis, i.e., the process of reversal of apoptosis. More specifically, the present invention provides methods and compositions useful for studying anastasis. In one embodiment, a tracking construct of the present invention comprises Lyn11-NES-ERT2-DEVD-rtTA-3xFLAG-DEVD-ERT2-NES. In another embodiment, a construct comprises Lyn11-NES-DEVD-rtTA-3xFLAG. In a further embodiment, a construct comprises ERT2-DEVD-rtTA-3XFLAG-DEVD-ERT2.
Public/Granted literature
- US20200283857A1 ANASTASIS BIOSENSOR CASPASE TRACKER Public/Granted day:2020-09-10
Information query
