Disclosed is a method for compiling an equivalent acceleration spectrum of creep under variable temperatures and loads. The method includes following steps: respectively carrying out a material high-temperature tensile test, material high-temperature creep tests and creep tests under two-stage variable temperatures and loads, and calculating values of a parameter p in a creep damage accumulation model under two-stage variable temperatures and loads; based on a nonlinear damage accumulation model under multi-stage variable temperatures and loads, calculating a damage D caused by a multi-stage variable temperatures and loads creep load spectrum by utilizing values of parameter p; based on the principle of consistency of damage D, transforming the multi-stage variable temperatures and loads creep load spectrum into an equivalent acceleration spectrum of a first-order maximum creep load, and finally compiling the equivalent acceleration spectrum of creep under variable temperatures and loads.