Systems and methods are provided for using logic-based compensation to optimize luminance uniformity of light emitting diode (LED) backlight panels employed for display panel assemblies such as liquid crystal displays (LCDs). These systems and methods may be implemented using a uniformity profile (e.g., uniformity lookup table “U-LUT”) in the LED backlight driving process to provide values to separately control luminance of different backlight segments of a LED backlight panel in order to improve backlight segment luminance uniformity.