Apparatus, systems, and methods to capture and combine patient vitals and image data are disclosed. An example apparatus includes an imaging device to capture imaging data of a patient; a patient monitor to capture non-imaging data of the patient; and a communication interface between the imaging device and the patient monitor to route the non-imaging data to the imaging device. The example imaging device is to combine the non-imaging data with the imaging data to form a combined data set to be processed to determine a clinical outcome.