Described are systems and methods for establishing and generating collections of sets that contain object identifiers based on user provided annotations for the object identifiers. A set may include one or more object identifiers and each object identifier may include one or more user provided annotations. Annotations from all object identifiers within a set are processed to form a set profile signature representative of the set. The set profile signatures are then compared between different sets to identify similar sets. Similar sets are included in a collection. Utilizing set profile signatures for a set formed based on user provided annotations provides useful relationships between sets that might otherwise not exist.