Neurostimulation devices and methods provide a plurality of electrodes placed around a patient head such that electrode have electrical paths through the brain to other electrodes. A controller controls current between sets of opposing electrodes through the patient brain to selectively stimulate a region of interest of the patient brain. Different sets of electrodes are used to provide electrical current pulse with different polarities such that a net potential is exposed to a region of interest in the brain that it above a neuron stimulation threshold while a net potential exposed to tissue outside the region of interest is below the threshold.