Invention Grant
- Patent Title: Crystalline substituted pyrazines as PGI2 receptor agonists
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Application No.: US17134796Application Date: 2020-12-28
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Publication No.: US11655218B2Publication Date: 2023-05-23
- Inventor: Toshio Fujiwara
- Applicant: NIPPON SHINYAKU CO., LTD.
- Applicant Address: JP Kyoto
- Assignee: NIPPON SHINYAKU CO., LTD.
- Current Assignee: NIPPON SHINYAKU CO., LTD.
- Current Assignee Address: JP Kyoto
- Priority: JP 2017187296 2017.09.28
- The original application number of the division: US16650390
- Main IPC: C07D241/26
- IPC: C07D241/26 ; C07D241/20

Abstract:
A main object of the present invention is to provide a novel crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid (hereinafter referred to as “Compound B”).
A form-I crystal of Compound B, which shows peaks at diffraction angles (2θ) of 6.4°, 8.1°, 9.5°, 10.9°, 13.2°, 15.7°, 17.0°, 19.5°, 20.3°, 21.0°, and 22.8° in a powder X-ray diffraction spectrum obtained using a Cu-Kα radiation (λ=1.54 Å).
A form-II crystal of Compound B, which shows peaks at diffraction angles (2θ) of 9.6°, 11.4°, 11.7°, 16.3°, 17.5°, 18.5°, 18.7°, 19.9°, 20.1°, 21.0°, and 24.6° in a powder X-ray diffraction spectrum obtained using a Cu-Kα radiation (λ=1.54 Å).
A form-I crystal of Compound B, which shows peaks at diffraction angles (2θ) of 6.4°, 8.1°, 9.5°, 10.9°, 13.2°, 15.7°, 17.0°, 19.5°, 20.3°, 21.0°, and 22.8° in a powder X-ray diffraction spectrum obtained using a Cu-Kα radiation (λ=1.54 Å).
A form-II crystal of Compound B, which shows peaks at diffraction angles (2θ) of 9.6°, 11.4°, 11.7°, 16.3°, 17.5°, 18.5°, 18.7°, 19.9°, 20.1°, 21.0°, and 24.6° in a powder X-ray diffraction spectrum obtained using a Cu-Kα radiation (λ=1.54 Å).
Public/Granted literature
- US20210114995A1 CRYSTALLINE SUBSTITUTED PYRAZINES AS PGI2 RECEPTOR AGONISTS Public/Granted day:2021-04-22
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