A roof system for a vehicle having a roof opening in a roof part thereof, comprises a closure which is movable by an operating mechanism including at least a guide rail extending in a longitudinal direction of the roof system. A slide which is slidable in the guide rail cooperates at least with a closure support. The slide comprises a body and at least two curves provided in the body and each cooperating with at least a cam. The cams are provided on at least the closure support and the curves have such extent that they cross each other between their ends. The curves are arranged in substantially parallel walls of the body of the slide that face away from each other.