Embodiments of the present invention provide a method and device for multi-AP beamforming (e.g., nulling) and spatial reuse to mitigate interference and improve the performance of MAP wireless networks. According to one embodiment, multiple APs agree to collaborate in multi-AP beamforming, transmissions of received PDDUs are measured to determine interference information, the APS generate interference maps, and the APs perform joint and Multi-AP beamforming in a first and second BSS to avoid/mitigate interference of the MAP wireless network. An RTS and CTS frame exchange sequence can be performed prior to Multi-AP beamforming between BSSs using a flag/indicator in the RTS frame to indicate coordinated transmission, or an UL trigger frame can be used to indicate a coordinated UL transmission.