Presently disclosed is a high load glyphosate herbicidal composition with high efficiency and low toxicity. The composition includes glyphosate as a mixture of potassium salts and glyphosate salt with monoisopropylamine (MIPA) of a glyphosate (acid equivalent) load of 400 to 600 g/L in balance with a surfactant system formed by an oxidized amine, an aliphatic alcohol, and a complexing agent, for the control of weeds in agricultural crops. The composition further includes adjuvants which promote a significantly more advantageous herbicidal efficacy than other known glyphosate formulations.