Some embodiments of the disclosure provide an artificial neural network system for recognizing a lesion in a fundus image. The system includes a pre-processing module configured to pre-process a target fundus image and a reference fundus image taken from one person separately, a first neural network (12) configured to generate a first advanced feature set from the target fundus image, a second neural network (22) configured to generate a second advanced feature set from the reference fundus image, a feature combination module (13) configured to combine the first advanced feature set and the second advanced feature set to form a feature combination set, and a third neural network (14) configured to generate, according to the feature combination set, a judgmental result of lesions.