A tissue specimen retrieval device includes a housing, an outer shaft extending from the housing, an end effector assembly extending from the outer shaft, an actuator associated with the housing, and an articulation mechanism operably coupled between the actuator and the end effector assembly. The articulation mechanism includes an articulation block supporting the end effector assembly thereon and is rotatable between first and second orientations to articulate the end effector assembly. A spring biases the articulation block towards the second orientation. An actuation sleeve is slidable relative to the articulation block, in response to actuation of the actuator, from an engaged position, wherein the actuation sleeve is disposed about and retains the articulation block in the first orientation, to a disengaged position, wherein the actuation sleeve is spaced from the articulation block such that the articulation block rotates to the second orientation to articulate the end effector assembly.