Invention Grant
- Patent Title: Treatment or prevention of cardiovascular events via the administration of a colchicine derivative
-
Application No.: US16952617Application Date: 2020-11-19
-
Publication No.: US11666545B2Publication Date: 2023-06-06
- Inventor: Mark Nidorf
- Applicant: Murray and Poole Enterprises, LTD.
- Applicant Address: GI Gibraltar
- Assignee: MURRAY AND POOLE ENTERPRISES LTD
- Current Assignee: MURRAY AND POOLE ENTERPRISES LTD
- Current Assignee Address: GI Gibraltar
- Agency: Biopharma Law Group, PLLC
- Priority: AU 12904828 2012.11.02 AU 12904868 2012.11.05
- Main IPC: A61K31/165
- IPC: A61K31/165 ; A61K45/06 ; A61K31/37 ; A61K31/616 ; A61K31/4365
Abstract:
A method for the treatment or prevention of a cardiovascular event in a subject with atherosclerotic vascular disease comprising the step of:
b) administering a therapeutically effective amount of a compound of formula (I), a known colchicine derivative and/or a salt thereof
wherein:
R1, R2, R3, R4, R9, R10, R11 and R12 independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, halogen, C1-4 haloalkyl, nitro, amino, C2-4 acylamino, C1-4 alkyl or dialkylamino, hydroxyl, C1-4 alkoxy, C1-4 alkylthio, a group of the formula —SO2N(Rx)2 or SO2Rx where Rx is C1-4 alkyl, C1-4 acyloxy, or optionally substituted phenyl, optionally substituted phenoxy;
R7 and R8 independently represent hydrogen, C1-4 alkyl or C1-4 acyl; and
R5′, R5″, R6′ and R6″ independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, halogen, C1-4 haloalkyl, nitro, amino, C2-4 acylamino, hydroxyl, C1-4 alkoxy or C1-4 alkylthio a group of the formula —SO2N(Rx)2 or SO2Rx where Rx is C1-4 alkyl, C1-4 acyloxy, or optionally substituted phenyl.
b) administering a therapeutically effective amount of a compound of formula (I), a known colchicine derivative and/or a salt thereof
wherein:
R1, R2, R3, R4, R9, R10, R11 and R12 independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, halogen, C1-4 haloalkyl, nitro, amino, C2-4 acylamino, C1-4 alkyl or dialkylamino, hydroxyl, C1-4 alkoxy, C1-4 alkylthio, a group of the formula —SO2N(Rx)2 or SO2Rx where Rx is C1-4 alkyl, C1-4 acyloxy, or optionally substituted phenyl, optionally substituted phenoxy;
R7 and R8 independently represent hydrogen, C1-4 alkyl or C1-4 acyl; and
R5′, R5″, R6′ and R6″ independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, halogen, C1-4 haloalkyl, nitro, amino, C2-4 acylamino, hydroxyl, C1-4 alkoxy or C1-4 alkylthio a group of the formula —SO2N(Rx)2 or SO2Rx where Rx is C1-4 alkyl, C1-4 acyloxy, or optionally substituted phenyl.
Public/Granted literature
- US20210069131A1 TREATMENT OR PREVENTION OF CARDIOVASCULAR EVENTS VIA THE ADMINISTRATION OF A COLCHICINE DERIVATIVE Public/Granted day:2021-03-11
Information query
