Invention Grant
- Patent Title: RelA inhibitors for biofilm disruption
-
Application No.: US16610376Application Date: 2018-05-14
-
Publication No.: US11666555B2Publication Date: 2023-06-06
- Inventor: Hai-Feng Ji , Garth David Ehrlich , Donald Carl Hall, Jr. , Jaroslaw E. Krol , John P. Cahill
- Applicant: Hai-Feng Ji , Garth David Ehrlich , Donald Carl Hall, Jr. , Jaroslaw E. Krol , John P. Cahill
- Applicant Address: US NJ Cherry Hill
- Assignee: DREXEL UNIVERSITY
- Current Assignee: DREXEL UNIVERSITY
- Current Assignee Address: US PA Philadelphia
- Agency: Mendelsohn Dunleavy, P.C.
- International Application: PCT/US2018/032560 2018.05.14
- International Announcement: WO2018/213185A 2018.11.22
- Date entered country: 2019-11-01
- Main IPC: A61K31/415
- IPC: A61K31/415 ; A61K45/06 ; A61K31/341 ; A61K31/43 ; A61K31/496 ; A61K31/506 ; A61K31/7008 ; C07D231/12 ; C07D307/20
Abstract:
Pharmaceutical compositions comprising a RelA enzyme inhibitor and a bactericidal antibiotic, wherein said RelA enzyme inhibitor binds to the RelA enzyme in bacteria to reduce biofilm formation and to degrade biofilms that have been formed. The pharmaceutical compositions can be used to treat bacterial biofilm diseases.
Public/Granted literature
- US20200069647A1 RelA Inhibitors for Biofilm Disruption Public/Granted day:2020-03-05
Information query
