Invention Grant
- Patent Title: Hexameric tetrahedral RNA nanostructures
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Application No.: US17053615Application Date: 2019-05-08
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Publication No.: US11666663B2Publication Date: 2023-06-06
- Inventor: Bruce A. Shapiro , Paul J. Zakrevsky , Luc Jaeger
- Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services , The Regents of the University of California
- Applicant Address: US MD Bethesda
- Assignee: The United States of America,as represented by the Secretary, Department of Health and Human Services,The Regents of the University of California
- Current Assignee: The United States of America,as represented by the Secretary, Department of Health and Human Services,The Regents of the University of California
- Current Assignee Address: US MD Bethesda; US CA Oakland
- Agency: Leydig, Voit & Mayer
- International Application: PCT/US2019/031356 2019.05.08
- International Announcement: WO2019/217576A 2019.11.14
- Date entered country: 2020-11-06
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K47/54 ; A61K47/69 ; B82Y5/00
Abstract:
Disclosed are nanostructures comprising a ribonucleic acid (RNA) scaffold comprising a hexameric tetrahedral core. The tetrahedral core may comprise four hexameric RNA nanorings linked together. Related pharmaceutical compositions, methods of modulating the expression of a target gene in a mammal, methods of treating or preventing a disease in a mammal, and methods of producing a hexameric tetrahedral RNA nanostructure are also disclosed.
Public/Granted literature
- US20210069345A1 HEXAMERIC TETRAHEDRAL RNA NANOSTRUCTURES Public/Granted day:2021-03-11
Information query
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