A fluid handling system includes a fluid handling device including an opening for introducing a fluid or discharging the fluid; a tube including a flange, where one end of the tube is for connection to the opening, and the other end of the tube is for connection to an introduction device for supplying the fluid or to a discharge device for discharging the fluid; a support member including a first through hole into which the tube is inserted, and movably supporting the tube; and a first elastic member including a second through hole into which the tube is inserted, and holding a part of the tube while the first elastic member is in contact with the flange and the fluid handling device or the support member.