A removable roof panel system for a vehicle, includes a frame structure configured to be mounted to a roof of the vehicle. A front panel is removably mounted to the frame structure and including a front glass panel and a front panel frame. A rear panel is removably mounted to the frame structure and includes a rear glass panel and a rear panel frame. The frame structure includes a trough portion and supports a first seal configured to be disposed between the roof of the vehicle and the front and rear glass panels and a second seal disposed between the front and rear panel frames and the frame structure. A front latch system releasably secures the front panel to the frame structure and a rear latch system releasably secures the rear panel to the frame structure.