A cargo loading system includes a drive unit extending along a length of a cargo area of an aircraft. The drive unit is configured to couple to a modular cargo structure via a handling member and to convey one or more cargo items coupled to the modular cargo structure. The cargo loading system further includes a rotation device and a driver. The rotation device is in contact with the drive unit. The driver is configured to apply torque to the rotation device to cause the drive unit to move the modular cargo structure within the aircraft.