Invention Grant
- Patent Title: Phenyl containing compound, intermediate thereof, preparation method therefor and application thereof
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Application No.: US17627965Application Date: 2020-07-14
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Publication No.: US11667604B2Publication Date: 2023-06-06
- Inventor: Jun He , Zhefeng Wang , Yuezhu Zhao , Yani Yang , Qinghui Fu , Wei Bian , Yuan Zhao , Chen Ge , Yue Zhang , Bing Yi , Minghao Niu , Jiuhui Zhang
- Applicant: SHANGHAI MODERN PHARMACEUTICAL ENGINEERING RESEARCH CENTER CO., LTD. , SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY
- Applicant Address: CN Shanghai
- Assignee: SHANGHAI MODERN PHARMACEUTICAL ENGINEERING RESEARCH CENTER CO., LTD.,SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY
- Current Assignee: SHANGHAI MODERN PHARMACEUTICAL ENGINEERING RESEARCH CENTER CO., LTD.,SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY
- Current Assignee Address: CN Shanghai; CN Shanghai
- Agency: Nath, Goldberg & Meyer
- Agent Joshua B. Goldberg
- Priority: CN 1910650358.1 2019.07.18
- International Application: PCT/CN2020/101842 2020.07.14
- International Announcement: WO2021/008516A 2021.01.21
- Date entered country: 2022-01-18
- Main IPC: C07C309/18
- IPC: C07C309/18 ; A61K9/107 ; A61K31/337 ; A61K47/20 ; A61P35/04

Abstract:
A phenyl-containing compound, an intermediate thereof, a preparation method therefor and an application thereof. Provided is a compound represented by formula I or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4 and R5 are independently hydrogen, C1-C6 alkyl, C1-C6 alkoxy or C(═O)OR8; where R8 is C1-C4 alkyl; R6 is (II), (III) or (IV); and R7 is —OH, —NH2, —NHCH3, —N(CH3)2 or C1-4 alkoxy. The compound has a low critical micelle concentration (CMC) and good dilution resistance and is capable of enclosing an insoluble drug to form a small-molecule micelle having a high drug loading capacity and good stability.
Public/Granted literature
- US20220274920A1 Phenyl Containing Compound, Intermediate Thereof, Preparation Method Therefor and Application Thereof Public/Granted day:2022-09-01
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