Invention Grant
- Patent Title: Compounds for imaging tau proteins that accumulate in brain
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Application No.: US17477479Application Date: 2021-09-16
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Publication No.: US11667628B2Publication Date: 2023-06-06
- Inventor: Makoto Higuchi , Tetsuya Suhara , Masahiro Maruyama , Meiei Cho , Hitoshi Shimada
- Applicant: National Institutes for Quantum and Radiological Science and Technology
- Applicant Address: JP Chiba
- Assignee: NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGY
- Current Assignee: NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGY
- Current Assignee Address: JP Chiba
- Agency: Foley & Lardner LLP
- Main IPC: C07D417/06
- IPC: C07D417/06 ; C07F7/18 ; C07D401/06 ; C07D405/06 ; C07D417/14 ; C07D277/64 ; A61K49/00 ; C07D401/14 ; C07D405/14

Abstract:
The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof:
wherein:
R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl;
R3 is hydrogen or halogen;
ring A is a benzene ring or a pyridine ring;
ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv):
in the formula (ii), Ra is alkyl;
R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and
represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.
wherein:
R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl;
R3 is hydrogen or halogen;
ring A is a benzene ring or a pyridine ring;
ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv):
in the formula (ii), Ra is alkyl;
R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and
represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.
Public/Granted literature
- US20220056020A1 NOVEL COMPOUNDS FOR IMAGING TAU PROTEINS THAT ACCUMULATE IN BRAIN Public/Granted day:2022-02-24
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