- Patent Title: Aqueous suspension compositions, formulations, and water dispersible dry compositions comprising 16alpha-bromo-3beta-hydroxy-5alpha-androstan-17-ketone and hydrates, derivatives, and analogs thereof
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Application No.: US17098314Application Date: 2020-11-13
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Publication No.: US11667665B2Publication Date: 2023-06-06
- Inventor: Yu Ge
- Applicant: SD Chem, Inc.
- Applicant Address: US CA San Diego
- Assignee: SD Chem, Inc.
- Current Assignee: SD Chem, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Mei & Mark LLP
- Agent Manni Li
- Main IPC: C07J1/00
- IPC: C07J1/00 ; A61K9/00 ; A61K31/5685 ; A61P1/00 ; A61P31/06 ; A61P37/06 ; A61P3/10 ; A61P35/00 ; A61K9/19 ; A61K47/34 ; A61K47/38 ; A61P11/06

Abstract:
Composition comprising a stable aqueous suspension formulation, which may be reconstituted from a water dispersible dry composition, comprising compound of Formula I in the form of particles stabilized in an aqueous suspension. It causes little or no injection site irritation and has superior properties over non-aqueous formulations. It stimulates autophagy, enhance innate immunity, down-regulates unproductive inflammation and exerts a Th1 immune bias. It demonstrates better efficacy in both in vitro and in vivo models.
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