Invention Grant
- Patent Title: Binding molecules that modulate a biological activity expressed by a cell
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Application No.: US16628547Application Date: 2018-07-06
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Publication No.: US11667714B2Publication Date: 2023-06-06
- Inventor: Cecilia Anna Wilhelmina Geuijen , Rinse Klooster , Cornelis Adriaan De Kruif , Paulus Johannes Tacken , Mark Throsby , Ton Logtenberg
- Applicant: Merus N.V.
- Applicant Address: NL Utrecht
- Assignee: Merus N.V.
- Current Assignee: Merus N.V.
- Current Assignee Address: NL Utrecht
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Priority: EP 180064 2017.07.06
- International Application: PCT/NL2018/050449 2018.07.06
- International Announcement: WO2019/009726A 2019.01.10
- Date entered country: 2020-01-03
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61P35/00 ; C07K16/30 ; C07K16/46 ; A61K39/00
Abstract:
The invention provides means and methods for inhibiting a biological activity of cells. In one embodiment the invention is concerned with a method of inhibiting a biological activity in a first or second cell mediated by the binding of two membrane proteins that are binding partners for each other. The mentioned biological activity is inhibited by providing the cells with an antibody or antibody like molecule that can bind to each of the mentioned binding partners and the binding blocks the binding of the two binding partners thereby inhibiting the mentioned biological activity.
Public/Granted literature
- US20200325227A1 BINDING MOLECULES THAT MODULATE A BIOLOGICAL ACTIVITY EXPRESSED BY A CELL Public/Granted day:2020-10-15
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