Methods and systems are provided for adjusting a location of a fuel injection in response to a substitution rate and a desired EGR flow. In one example, a method may include injecting a first fuel to a combustion chamber via a direct injector positioned to inject directly into the combustion chamber, injecting a second, different, fuel to the combustion chamber via an exhaust port injector positioned to inject toward an exhaust valve of the combustion chamber, and combusting the first and second fuels together in the combustion chamber.