A blade structure with multiple blade angles and a heat dissipation device include: the blade structure consisting of a plurality of blades with different blade angles. The blade angles of the blades decrease from an inner side to an outer side along a longitudinal direction of the blade structure. The blades have top portions on the same surface and are integrally formed in one piece. A joint between the blades has a transition part. The blade structures are evenly mounted on the hub and are connected to an outer frame. The hub and the blade structures are integrally formed in one piece, or the hub, the blade structures, and the outer frame are integrally formed in one piece. The blade structures can guide air flow to reduce air shedding, suppress backflows, reduce vortex turbulence, increase air volume, improve heat dissipation efficiency, and reduce vortex noise and vibration.