Systems and methods facilitating fault tolerance for transaction mirroring are described herein. A method as described herein can include receiving a commit command for a data transaction from an initiator node of the system, wherein the data transaction is associated with a first failure domain, and wherein the commit command is directed to a primary participant node and a secondary participant node of the system; determining whether a response to the commit command has been received at the primary participant node from the secondary participant node in response to the receiving; and, in response to determining that the response to the commit command was not received at the primary participant node, indicating that the secondary participant node is invalid in a data store associated with a second failure domain that is distinct from the first failure domain.