A theft-proof packaging system includes a product package including a compartment configured to encapsulate a product. The compartment is in a non-surrounding environmental state, the non-surrounding environmental state being either pneumatically pressurized above a surrounding environment or pneumatically vacuumized below the surrounding environment. A pressure sensor inside the compartment includes a switch, the switch configured to disconnect and connect a power source to a transmitter, wherein the switch is configured to disconnect the power source from the transmitter in the presence of the non-surrounding environmental state inside the compartment and the switch is configured to connect the power source to the transmitter when the compartment equalizes to the surrounding environment. A receiving unit is disposed remote from the product package and receives the signal from the transmitter and sounds an alarm. A passive RFID tag may be located within the compartment and detected when passing through a walk-through scanner.