System and methods are provided for detecting impairment of an individual. The method involves operating a processor to: receive at least one image associated with the individual; and identify at least one feature in each image. The method further involves operating the processor to, for each feature: generate an intensity representation for that feature; apply at least one impairment analytical model to the intensity representation to determine a respective impairment likelihood; and determine a confidence level for each impairment likelihood based on characteristics associated with at least the applied impairment analytical model and that feature. The method further involves operating the processor to: define the impairment of the individual based on at least one impairment likelihood and the respective confidence level.